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This may be closely related to the release of signaling molecules such as monoamine neurotransmitters, the glutamatergic system, the gut-microbiota-brain axis, pro-inflammatory cytokines and the endogenous opioid peptide system

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Neuropharmacology 155:98103 Zaitone SA, Abo-Elmatty DM, Shaalan AA (2012) Acetyl-L-carnitine and -lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinsons disease therapy