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However, when inflammation becomes chronic, it contributes to the development and progression of various diseases [17]

Third, biomarker deficiencies, where current indicators (e.g., malondialdehyde for lipid peroxidation) lack spatiotemporal resolution, necessitating advanced dynamic imaging probes (e.g., FRET-based disulfide bond sensors)

465,466,467,468 In RA, mitochondrial dysfunction drives chronic synovial inflammation despite preserved mitochondrial mass

However, further large-scale, well-controlled studies are needed to confirm its efficacy and to determine optimal dosing strategies

UVvis spectra were acquired using a Multiskan SkyHigh microplate spectrophotometer (ThermoFisher Scientific) and 96-well plates (Corning) or quartz cuvettes using SkanIt software