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However, some folks find that using essential oils on the more sensitive tissues of the vagina and anus can cause further irritation, even when properly diluted in a suppository formula

Furthermore, a strong correlation of 0.76 (CI: 0.71 - 0.81

doi: 10.1167/iovs.18-26248

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IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells

Interestingly, this effect of male sex in hastening the onset of SP-MS and disability accrual has not been observed in more recent studies where a higher proportion of MS patients are receiving high-efficacy disease modifying therapies (30, 31), suggesting that the autoimmune inflammation may be a factor in the effect of male sex on progression