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An overproduction of ROS can overwhelm the cellular antioxidant defenses, thereby causing oxidative stress [67]

10.1016/j.redox.2024.103189 237 MilczarekR.HallmannA.SokoowskaE.KalethaK.KlimekJ

M.PereiraD

In both behavioural despair paradigms, the antidepressant effects of SERT increased significantly with SILY at a concentration of 280 mg/kg of feed, although it decreased at 140 mg/kg of feed, suggesting that high concentrations of SILY could elicit an additive beneficial effect