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Recently, the metabolic pathways of M1/M2 macrophages have garnered increasing attention from researchers, leading to their adoption in macrophage diagnosis and therapeutic exploitation

Meanwhile, vitamin C itself scavenges ROS in aqueous environments, particularly in the cytoplasm and extracellular fluids

It produces m drop accompanied by an increased ROS production, glutathione depletion, and catalase activity, producing release of cytochrome c, increase of Bak pro-apoptotic protein, and decrease anti-apoptotic proteins Bcl-XL and heat-shock proteins (HSP-90 and HSP-70) (60)

10.1099/00221287-138-10-2021 J

CrisolLMatorrasRAspichuetaFExpsitoAHernndezMLRuiz-LarreaMBet al

doi: 10.1007/s00404-015-3646-9