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Here, we summarized the role of the vicious cycle of mitochondrial damage and ROS accumulation in RA and introduced potential drugs that target mitochondria or scavenge ROS for RA treatment, with the aim of providing some help for the clinical treatment of RA ( Table 1 )

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Additionally, we employed a genetic knockout of Caspase Recruitment Domain-9 (CARD9), which impairs the immune response against fungi

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