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However, this selectivity has only been observed under specific in vitro culture conditions and cannot be directly generalized as a universal effect in vivo or in patients, and the experimental background limitations should be noted when citing this finding

Acknowledgments Figures were created using BioRender (publication licenses: and and Datawrapper ( Guo X.Y., Song D.Y., Wu M.Y., Zhang J.Q., Li J.Y., and Yuan L., Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy. MedComm 6, no

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In addition, using other NMDAR antagonists, the association of fluoxetine and amantadine also induced robust significant increases of both BDNF protein and mRNA gene expression in rodent brain [88]

Metabolic Health Improved glycemic control: Helps blunt sharp post-meal glucose spikes, which supports energy balance and reduces insulin demand