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This dual action external peptide supply plus stimulation of endogenous upregulation may produce more sustained neurological effects than supplementing a single growth factor alone

We induced abdominal compartment syndrome (intra-abdominal pressure in thiopental-anesthetized rats at 25 mmHg (60 min), 30 mmHg (30 min), 40 mmHg (30 min), and 50 mmHg (15 min) and in esketamine-anesthetized rats (25 mmHg for 120 min)) as a model of multiple occlusion syndrome

Research efforts must continue with the ultimate goal of preventing neuronal damage and preserving normal cognitive functioning