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During pathological conditions, cytokines can also stimulate inducible nitrogen oxide synthase (iNOS) which results in the production of NO in astrocytes and microglial cells (Murphy, 2000), which can then combine with superoxide radicals to form the aforementioned peroxynitrite, facilitating excitotoxicity (Leist et al., 1997) and DNA damage, ultimately leading to cell death (Xia et al., 1996)

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55 In another study from Belgium, 2 groups of children with ASD demonstrated a 71.4% (n = 84) and 75.6% (n = 82) prevalence of at least one FRAA as compared to 3% of healthy children

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