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Untreated, BH4 deficiency with high phenylalanine can lead to developmental delays, muscle dysfunction, cognitive impairment, and sometimes epilepsy.[ref] Rare mutations in different genes in the BH4 pathway can cause different genetic conditions

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The expansion to concave containers is also explored, but proves to be more challenging as the required number of quadratic constraints quickly becomes prohibitive

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These results, coupled with our early observations, 20 led us to conduct a Phase Ib clinical trial 70 evaluating Enza plus venetoclax (ABT-199) in 10 patients with mCRPC (NCT03751436), and our correlative studies suggested potential therapeutic benefit of this combination in a subset of mCRPC patients (Fig