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The effective concentration in cellular assays is 10 to 100 nM, with loss of efficacy at higher concentrations

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Preventive strategies are integral to comprehensive Thalassemia management, reducing disease burden for families and health systems while enabling at-risk couples to make empowered reproductive decisions

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Symptoms of vitamin B12 deficiency Other various symptoms of B12 deficiency include: A swollen, inflamed tongue Dizziness Shortness of breath Pale skin Muscle weakness Numbness or tingling in hands and feet Tiredness (low energy) Weight loss Infertility Irregular or increased heartbeats Constipation Appetite loss Flatulence Low mood (depression) High blood pressure or very low blood pressure Vitamin B12, Vitamin B6 and Folate There is a strong interrelationship between vitamin B12, vitamin B6 and folate (also known as vitamin B9)

While pain symptoms can be treated with medication, if the underlying cause is not treated, further serious complications can occur