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In fact, -synuclein has been demonstrated to disturb the translocation of nuclear-encoded mitochondrial proteins into the mitochondria by binding to translocase of the outer membrane (TOM)20 in both rotenone-treated and human -synuclein-overexpressing animal models

Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2)

Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells

pSS was diagnosed according to the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria ( Histological staining The LSG samples were fixed in fresh 4% neutral formaldehyde overnight, placed into an automatic tissue dehydrator for dehydration, embedded in paraffin, and cut into 5-mm-thick serial sections for haematoxylin and eosin (HE) and immunohistochemical (IHC) staining

Further studies demonstrated that sustained macrophage activation is essential for the maintenance of psoriasiform inflammation (100)

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